Antibodies

Antibodies

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IgG about 80 % of antibodies in serum
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IgG provides long term protection because it persists for months and years after the prescence of the antigen that has triggered their production
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IgG They can leave the blood cells and move to ares of inflammation
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IgG Monomer
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IgG Crosses the placenta providing the foetus with passive immunity
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IgG Protect against bacteris, viruses, neutralise bacterial toxins, trigger compliment protien systems and bind antigens to enhance the effectiveness of phagocytosis
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IgA 10-15% of antibodies
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IgA consists of two monomners joined togther
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IgA The most common form of antibodies in mucous membranes and body secretion. E.g. mucus, saliva, tears, breast milk
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IgA Main function is to bind antigens on microbes before they invade tissues. It aggregates the antigens and keeps them in the secretions so when the secretion is expelled, so is the antigen
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IgM Make up 10-15% of Antibodies
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IgM Large size so do not leave the blood vessels - Pentamer
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IgM Involved in the ABO blood group antigens on the surface of RBCs
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IgM Effective in aggregating antigens because it has ten binding sites
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IgM Involved in compliment
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IgM Enhance ingestions of cells by phagocytosis
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IgD 0.2% of serum antibodies
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IgD Found in te blood, lymph and especially on the surface of B cells. We have limited knowledge of their function
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IgD Monomer
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IgE 0.0002% of antibodies
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IgE Bind to mast cells and basophils wich participate in the immune response
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IgE When and antigen such as pollen binds to ths antibody, the mast cell or basophil releases histamine..


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IgE Involved in allergicc reactions
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IgE It attract complement and phagocytic cells..