Reactive Thrombocytosis

Secondary or Reactive Thrombocytosis (High Platelet Count) :

Platelets are acute-phase reactants; therefore, they increase in response to various stimuli, including systemic infections, inflammatory conditions, bleeding, and tumors. This is called reactive or secondary thrombocytosis, which is a benign form of thrombocytosis. In contrast, clonal thrombocytosis (primary or essential thrombocytosis) is an unregulated abnormality of platelet production due to a clonal expansion of bone marrow progenitor cells.

Etiologic conditions associated with secondary thrombocytosis (reactive thrombocytosis) include the following:

Infection and inflammatory disorders
Postsplenectomy or hyposplenism
Malignancy
Trauma
Chronic inflammatory conditions
Hemorrhage, blood loss, or both
Iron-deficiency anemia
Rebound thrombocytosis
Asplenia (anatomic or functional)
Idiopathic

Treatment :-

The primary treatment of secondary thrombocytosis (reactive thrombocytosis) should address the underlying cause of the thrombocytosis. For example, iron supplementation may normalize platelet counts in patients with thrombocytosis secondary to inflammatory bowel disease. In general, no treatment is indicated to directly reduce the platelet count