Cells in intestine that migrate to surface | MDS entrance preaparations

Cells in intestine that migrate to surface include the following EXCEPT: 

A. Paneth cells 

B. Enterocytes 
C. Goblet cells 
D. . Enteroendocrine cells

Ans. A. Paneth cells.

• They are found only in deeper part of the intestinal crypts ofLieberkuhn.

• Unlike other lineages, Paneth cells migrate to the crypt base.

• They have a long life-span of —28 days.

• Paneth cells are noted for their prominent secretory apparatus.

• Granules are readily visulaized using a variety of stains including the Phloxine-Tartrazine histochemical stain.

• They are very rich in ZINC.

• Paneth cells provide host defense against microbes in the small intestine

• They are known to produce lysozyme, which destroys bacteria. They are also known to secrete defensins.

• In addition to defensins, Paneth cells secrete lysozyme and phospholipase A2, both of which have clear antimicrobial activity. This battery of secretory molecules gives Paneth cells a potent arsenal against a broad spectrum of agents, including bacteria, fungi and even some enveloped viruses.