Heinz bodies | MDS Preparations 09818001730

Heinz bodies are found in all conditions except: 

A. α-thalassemia 
B. G6PD deficiency
C. Unstable hemoglobinopathy 
D. Lead poisoning

Ans: D. . Lead poisoning

•Denatured Hb is precipitated with RBCs in the form of inclusions known as Heinz bodies.

•Condition m which Heinz bodies found are:

1.Glucose-6-phosphate dehydrogenase deficiency this disorder produce no symptom unless the RBC subjected to oxidant injury e.g. primaquine and sulfonamide.

2. α-thalassemia.    

3. HbH disease A variant of a-thalassemia.

4. Unstable-Hb hemoglobinopathy.

•Congenital non-spherocytic haemolytic anaemia results because of unstable hemoglobinopathy.

• Lead poisoning: 90% of absorbed lead accumulate in metaphysis of bone and 10% accumulate in brain, liver, kidney and bone marrow.

- Effect of lead poisoning on haemopoietic system:-

•Microcytic hypochromic anaemia.

•Prominent basophilic stippling of erythrocytes.

Other condition in which basophilic stippling is seen are following:

- Aplastic anaemia

- Thalassemia

- Myelodysplasia

- Infection.