Tuesday, 5 January 2016

Post-Transcriptional modification of RNA


Which of the following is not a post-transcriptional modification of RNA?

A. Splicing 
B. 5- capping
C. 3'-poly adenylation 
D. Glycosylation

Answer. D. Glycosylation
Glycosylation has not been mentioned as a post-transitional modification of RNA.
5' - capping: Is required both for efficient translation initiation and protection of 5' - end of MRNA from attack by 5'-3' exonucleases.

3' - poly adenylatlon: Added to 3'-end of mRNA molecules in a post transcriptional processing step. This appears to protect the 3'-end of mRNA from 3' - 5' exo-nuclease attack.

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